These leaders have access to the same units and buildings/wonders/districts, but they have different agendas and bonuses, which allows for different playstyles. Ideal would be a scenario editor along the lines of Civ IV, to enable things like TSL, or to construct real scenarios in history. Something like Civ V's 'Really Advanced Setup' mod would be more useful.
Added in Rise and Fall: Chandragupta - India alternate leader Genghis Khan - Mongolia Poundmaker - Cree Seondeok - Korea Wilhelmina - Netherlands Tamar - Georgia Robert the Bruce - Scotland Lautaro - Mapuche Shaka - Zulu Soon to be added in The Gathering Storm: Mathias.
As you trade, you can get gossip information, and from interaction gain more knowledge about other Leaders through espionage. The Civilizations and known unique Leaders or Units / Buildings listed so far in Civilization VI.
While playing the game, press to display the debug panel. Find the DebugPanel 0 line and change it to DebugPanel 1. Each Leader will have a fixed agenda as well as a 'hidden' Agenda. Use a text editor to edit the Config.ini file in your Steam Apps folder or the \Documents\My Games\Sid Meier’s Civilization 6\ directory.